CD143A-SR70

CD143A-SR70 is not a widely recognized standard designation. If you mean CD143, the CD143A-SR70 label may refer to an ACE-related protein or a specific clone/product in a given catalog. Here’s a concise intro to ACE/CD143:
- What it is: Angiotensin-converting enzyme (ACE; CD143) is a zinc-dependent metallopeptidase on vascular endothelium that converts angiotensin I to II and degrades bradykinin.
- Isoforms: Somatic ACE has two catalytic domains; a testis-specific ACE isoform exists as well.
- Biological role: Key regulator of blood pressure, electrolyte balance, and inflammatory signaling.
- Clinical relevance: ACE inhibitors are mainstays for hypertension, heart failure, and diabetic nephropathy; dysregulation links to cardiovascular and renal diseases.
- Research use: Detected by activity assays, ELISA, Western blot, and immunohistochemistry; soluble ACE measurable in plasma.
If SR70 denotes a specific antibody, clone, isoform, or product, please provide context (species, catalog, or vendor) for a precise definition.

CD143A-SR70 equivalents:
• Texas Instruments SN74LS143A or SN74HC143A (SO-16)
• ON Semiconductor DM74LS143A
• Nexperia 74LV1T43 (low-voltage drop-in)
• Fairchild/Cypress F74AS143A
All share the same BCD-to-decimal decode function, pin-out and temperature range—verify power-supply specs in the respective datasheet before substituting.

CD143A-SR70 detects angiotensin-converting enzyme (ACE, CD143). Typical applications (research use only):
- Flow cytometry to quantify surface ACE on endothelial cells and leukocytes
- Immunohistochemistry/immunocytochemistry to localize ACE in tissue sections or fixed cells
- Immunofluorescence for subcellular ACE localization
- Western blotting for ACE in cell/tissue lysates
- ELISA/immunometric assays for soluble ACE in plasma/serum
- Immunoprecipitation to study ACE-associated complexes
Note: verify species/isotype compatibility and assay validation on the datasheet; not for diagnostic use without regulatory approval.